Therapeutic Approaches of Acute Thoracic Syndrome in Patients with Falciform Disease

Sickle cell disease (SCD) is an autosomal recessive inheritance disorder that affects the beta-globin gene and results in the replacement of the amino acid glutamic acid by valine in the β chain of the hemoglobin molecule, producing erythrocytes with defective forms and functions. A range of pathological conditions is associated with SCD, however, one in particular stands out by gravity. Acute thoracic syndrome (STA), characterized by the presence of pulmonary infiltrates associated with a clinical symptom such as chest pain, cough, wheezing, tachypnea and fever, is considered a leading cause of death in patients with sickle cell disease. Early diagnosis and introduction of an effective approach to complication are needed to improve outcomes and minimize associated morbidity and mortality. Risk factors associated with STA in the SCD Abdominal surgery for splenectomy and cholecystectomy [19] Hypersensitivity [20,21] Smoking [20,21] Asthma [22] Infections [9,23-25] Post-Surgical Hypoventilation [9,23-25] Fatty Embolism [9,23-25] Table 1: Key risk factors for a sickle cell patient. Citation: Destefani AC, Costa DS, Zanardo TEC, Taufner GH (2017) Therapeutic Approaches of Acute Thoracic Syndrome in Patients with Falciform Disease. J Blood Lymph 7: 165. doi: 10.4172/2165-7831.1000165